Workshop on Information Processing in the Biological Organism (A Systems Biology Approach)
November 4-5, 2003
Four Points Sheraton, Bethesda, Maryland (5 minutes walk from NIH)
The workshop will be a "satellite" meeting prior to the NIH
Biomedical Information Science and Technology Initiative (BISTI)
Symposium, "Digital Biology: the Emerging Paradigm" to be held
November 6 and 7, 2003 in Natcher Auditorium on the main NIH campus.
See URL: http://www.bisti.nih.gov/2003meeting/.
- SCIENTIFIC CONTACTS:
Fred S. Roberts, Chair, DIMACS / Rutgers University, email@example.com
- Eduardo Sontag, Co-chair, Rutgers University, http://www.math.rutgers.edu/~sontag
- CONTACT FOR ORGANIZATIONAL MATTERS:
Christine Spassione , DIMACS / Rutgers University, firstname.lastname@example.org
Presented under the auspices of the
Special Focus on Computational Molecular Biology and sponsored by the National Science Foundation.
The workshop will investigate information processing in biological
organisms from the general point of view of systems
biology. Traditional biological research has aimed to understand
isolated parts of a cell or organism. It has achieved dramatic
technological breakthroughs in understanding genes and proteins. The
potential for dramatic new biological knowledge arises from
investigating the complex interactions of many different levels of
biological information. This is the heart of the systems approach to
biology. It is aimed at studying genomic DNA, mRNA, proteins, and
informational pathways and informational networks in conjunction,
looking for "system-level" understanding. Systems biology requires an
understanding of the basic system structures (the networks of gene
interactions and biochemical pathways) and it requires an
understanding of the dynamics of systems - how they change over time
through metabolic changes, modifications in biochemical makeup,
etc. Understanding the biological systems from this point of view can
be greatly aided by the use of powerful mathematical and computer
models. In turn, the systems understanding of biological systems can
provide insights that might be useful for computer and information
QUESTIONS TO BE ADDRESSED:
Information processing is a key aspect of biological systems and the
workshop will concentrate on this aspect of systems biology. In
general terms, the workshop will seek to answer the following
MAJOR SCIENTIFIC TOPICS:
- (1). What model systems concerning information processing in the
biological organism are of broad utility to systems biology?
- (2). What are the mathematical foundations relevant to the systems
biology approach to the study of information processing in biological
organisms, and specifically what algorithms are of broad and central
utility for this topic?
- (3). What is the next generation of reference resources needed for
research in this field?
- (4). How can the study of selected information processing processes within biological systems inform other disciplines, including computer science?
The workshop will be organized around four main topics:
- (a). Genetics to gene-product information flows, including temporal
and spatial aspects.
- (b). Signal fusion within the cell.
- (c). Cell-to-cell communication.
- (d). Information flow at the system level, including environmental
Next: Call for Participation
Contacting the Center
Document last modified on August 13, 2003.