Presented under the auspices of the Special Focus on Computational Molecular Biology and sponsored by the National Science Foundation.
Tuesday, November 4, 2003 8:15 - 9:00 Registration 9:00 - 9:15 Opening Remarks: Fred Roberts, Rutgers University: Program Chair Mitra Basu, NSF Eric Jakobsson, NIH 9:15 - 10:10 Keynote Address: Systems Biology: Deciphering Life Leroy Hood, Institute for Systems Biology 10:10 - 10:30 Break 10:30 - 12:45 Signal Fusion within the Cell Moderator: Leslie Loew, University of Connecticut Health Center Keynoter: Signaling in a Molecular Jungle Dennis Bray, Cambridge University Confirmed Speakers: Quantitative Experiments and Modeling of PDGF Receptor Signaling Jason Haugh, North Carolina State University; Analysis of a Cell Signaling Network Ravi Iyengar, Mt. Sinai Information transfer in signaling pathways: Gradient sensing Andre Levchenko, Johns Hopkins University 12:45 - 1:45 Lunch 1:45 - 4:00 Cell to Cell Communication Moderator: Stanislav Shvartsman, Princeton University Keynoter: Small Talk: Cell-to-Cell Communication in Bacteria Bonnie Bassler, Princeton University Confirmed Speakers: Counter-Intuitive Insights from Spatially Realistic Simulations of Synaptic Transmission Joel Stiles, Carnegie Mellon University Interrogative Cell Signaling: How cells perceive their context H.Steven Wiley, Pacific Northwest National Laboratory Oocytes on "cell" phones - EGFR signaling in Drosophila Joseph Duffy, Indiana University 4:00 - 4:20 Break 4:20 - 5:50 Discussion Groups Meet Separately (One corresponding to each Session topic) 7:00 Dinner* After-Dinner Speaker*: Juan Enriquez, Harvard Business School Life Science Project * The banquet and speaker are joint with the other BISTI satellite meeting on "Information Science Standards to Enable Biomedical Research" being organized in collaboration with the National Institute of Standards and Technology and being held in the same hotel on the same dates as our meeting. See URL: http://www.nist.gov/director/NIH/workshop.htm Wednesday, November 5, 2003 8:30 - 10:45 Genetics to Gene Product Information Flows Moderator: Gustavo Stolovitzky, IBM Keynoter: Learning Predictive Models of Cellular Systems David Gifford, MIT Confirmed Speakers: Inferring Dynamic Architecture of Cellular Networks by Perturbation Response Analysis Boris Kholodenko, Thomas Jefferson University; Reconstructing synthetic biological networks using pair-wise correlation analysis Gustavo Stolovitzky, IBM Dynamics of the p53-mdm2 feedback loop in living cells, and the design-principles of biological feedback Galit Lahav and Uri Alon, Weizmann Institute of Science 10:45 - 11:05 Break 11:05 - 12:05 Are There Genuinely New Challenges in Computer Science, Math, and Physics Arising from Information Processing in the Biological Organism?" Moderator: Eduardo Sontag, Rutgers University Confirmed Speakers: Systems Biology as a Generator of New Mathematics Eduardo Sontag, Rutgers University (Mathematics and BIOMAPS Institute) The Challenge of Understanding Bio-molecular Specificity Anirvan Sengupta, Rutgers University (Physics) Challenges for computer science and math as a part of Systems Biology Benno Schwikowski, Institute for Systems Biology Panel Discussion 12:05 - 1:05 Lunch 1:05 - 3:20 Information Flow at the System Level Moderator: Modeling Tumors As Complex Dynamic BioSystems Tom Deisboeck, Harvard University Keynoter: Information Flow at the Systems Level: The Organization and Modeling of Experimental Data Across Multiple Scales of Biological Analysis Raimond Winslow, The Johns Hopkins University School of Medicine & Whiting School of Engineering Confirmed Speakers: Computational models of cortico-striatal-hippocampal interaction during learning: Implications for neurological disorders of memory Mark Gluck, Rutgers University Multiscale Complexity in Health and Information Loss with Aging and Disease Ary Goldberger, Harvard University The Fluid Organs of Immunity: Phase transitions in bacterial pathogenesis Tom Kepler, Duke University 3:20 - 3:40 Break 3:40 - 4:40 Discussion Groups 4:40 - 5:20 Closing Plenary Session for Discussion Group Reports and Presentation Note: The moderators of the discussion groups will stay on to help prepare recommendations for the BISTIC Symposium.