This course is presented as part of the BioMaPS Summer School. It is jointly sponsored by the BioMaPS Institute for Quantitative Biology, the Center for Discrete Mathematics and Theoretical Computer Science (DIMACS), the Rutgers Center for Molecular Biophysics and Biophysical Chemistry (MBBC), the Program in Mathematics and Molecular Biology based at Florida State University (PMMB) and the Rutgers Center for Systems and Control (SYCON).
Presented under the auspices of the DIMACS/BioMaPS/MB Center Special Focus on Information Processing in Biology.
Monday, June 6, 2005 8:30 - 9:00 Breakfast and Registration 9:00 - 9:15 Welcome and Opening Remarks Paul Ehrlich, BioMaPS Administrative & Assoc. Graduate Program Director Introduction to the course 9:30 - 10:30 What is signal transduction? Stanislav Shvartsman, Princeton University - Genomics Institute, Chem. Eng. 10:30 - 11:00 Break 11:00 - 12:00 Stanislav Shvartsman (continued) 12:00 - 2:00 Lunch 2:00 - 3:00 Overview of signaling in bacteria Igor Zhulin, Georgia Tech- Biology 3:00 - 3:15 Break 3:15 - 4:15 Igor Zhulin (continued) 5:15 Reception 6:00 Dinner Tuesday, June 7, 2005 9:30 - 10:30 Introduction to two-component signaling Ann Stock, UMDNJ - Biochemistry 10:30 - 11:00 Break 11:00 - 12:00 Ann Stock (continued) 12:00 - 1:15 Lunch 1:15 - 2:15 Introduction to bacterial motility & chemotaxis Robert Bourret, University of North Carolina - Microbiology 2:15 - 2:30 Break 2:30 - 3:30 Robert Bourret (continued) 3:30 - 4:00 Break 4:00 - 4:30 Molecular evolution of the MCP signaling domain Roger Alexander, Georgia Tech-Biology 4:30 - 5:00 Significance of alternate binding modes of chemotaxis regulator, cheY with C-terminal peptide of its phosphatase, cheZ Jayita Guhaniyogi, University of Medicine and Denistry of NJ-Biochemistry Wednesday, June 8, 2005 9:30 - 10:00 Practical lessons concerning collaboration between experimentalists & modelers Robert Bourret, University of North Carolina - Microbiology 10:00 - 11:00 Adaptation and signal processing in bacterial chemotaxis Ned Wingreen, Princeton University - Molecular Biology 11:00 - 11:30 Break 11:30 - 12:30 Ned Wingreen (continued) 12:30 - 2:00 Lunch 2:00 - 3:00 Receptor interaction and signal amplification in bacterial chemotaxis Yuhai Tu, IBM 3:00 - 3:15 Break 3:15 - 4:15 Introduction to noise in biological systems William Bialek, Princeton University - Physics 4:15 - 4:30 Break 4:30 - 5:30 Noise in bacterial gene expression Alexander van Oudenaarden, MIT - Physics Thursday, June 9, 2005 9:30 - 10:30 Pushing the envelope: How E. coli copes with external stress Tom Silhavy, Princeton University - Molecular Biology 10:30 - 11:00 Break 11:00 - 12:00 Continuous control in bacterial regulatory circuits Mark Goulian, University of Pennsylvania - Physics 12:00 - 4:00 Lunch and Poster Session Friday, June 10, 2005 9:30 - 10:00 Modeling spatial oscillations of Min proteins in round bacteria Kerwyn Huang, Princeton University- Molecular Biology 10:00 - 10:30 Evolutionary design principles of a bacterial signaling network Kilian Bartholome, University of Freiburg-Molecular Biology 10:30 - 11:30 Quorum sensing: cell-to-cell communication in bacteria Bonnie Bassler, Princeton University - Molecular Biology 11:30 - 11:45 Closing Remarks