DIMACS Princeton Theory Seminar
Title:
The Mathematics of Virus Shell Assembly
Speaker:
- Bonnie Berger
- MIT
Place:
- Room 302, Computer Science Building
- Princeton University
Time:
- 1:30 PM
- Thursday, April 27, 1995
Abstract:
Viruses have shells made of repeated protein subunits surrounding their
genetic information. Many viruses, including polio, herpes, and AIDS,
have icosahedral-shaped shells. It is not understood how these shells
self-assemble from hundreds of similar protein subunits. A resolution
to this quesiton is important because it might eventually result in
mechanisms for interrupting shell formation and interfering with the
infection process. In the talk, I will describe surprisingly simple
sets of local rules that may explain the self-assembly of nearly all
icosahedral viruses, including some whose structures have puzzled
researchers. With these local rules, we can simulate the assembly
process computationally, and design a "toolkit" that will allow
biologists to study virus shell assembly on a computer screen.
This is joint work with Peter Shor, Lisa Tucker-Kellogg, and Jonathan King.
Host: Andrew Yao, yao@cs.princeton.edu
Document last modified on April 19, 1995