DIMACS Special Seminar

Title: Classifying Disease Models Using Regular Polyhedral Subdivisions

Speaker: Debbie Yuster, Columbia University

Date: Wednessday, February 21, 2007 4:30 pm

Location: DIMACS Center, CoRE Bldg, Room 433, Rutgers University, Busch Campus, Piscataway, NJ


Genes play a complicated role in how likely one is to get a certain disease. Biologists would like to model how one's genotype affects their likelihood of illness. I will discuss some classical disease models, as well as our new classification of two-locus disease models, where each model corresponds to an induced subdivision of a point configuration (basically a picture of connected dots). Our models reflect epistasis, or gene interaction. This work is joint with Ingileif Hallgrimsdottir. For more information, see our preprint at arXiv:q-bio.QM/0612044