DIMACS Workshop on Complexity in Biosystems: Innovative Approaches at the Interface of Experimental and Computational Modeling
April 8 - 10, 2002
DIMACS Center, CoRE Building, Rutgers University, Piscataway, NJ
- Organizers:
- Thomas Deisboeck, Harvard Medical School, deisboec@helix.mgh.harvard.edu
- Lee Segel, Weizmann Institute, lee@wisdom.weizmann.ac.il
- Eduardo Sontag, Rutgers University, sontag@gauss.rutgers.edu
- Raimond Winslow, The Johns Hopkins University, rwinslow@bme.jhu.edu
Presented under the auspices of the Special Fodus on Computational Molecular Biology.
Workshop Program:
MONDAY, April 08: "Molecular & Intracellular Level"
08:00 - 08:45 Breakfast & Registration
09:00 - 09:05 Welcome and Greeting:
Fred S. Roberts, DIMACS Director
09:05 - 09:15 Welcome and Greeting from Workshop Organizers:
Thomas Deisboeck, Harvard Medical School
Lee Segel, Weizmann Institute
Eduardo Sontag, Rutgers University
Raimond Winslow, The Johns Hopkins University
09:15 - 10:15 Keynote address: Integrative Systems Biology:
Genomics, Proteomics, and Computation
L. Hood, Institute for Systems Biology
10:15 - 10:45 Coffee Break
10:45 - 11:30 Linking Genomics to Function via Metabolic
Phenotyping
G. Stephanopoulos, Massachusetts Institute of Technology
11:30 - 12:15 Designer Gene Networks
J. Collins, Boston University
12:15 - 01:45 Lunch
01:45 - 02:30 The Architecture of Complexity: From the
Topology of the World Wide Web to the
Cell's Protein and Metabolic Network
A.-L. Barabasi, University of Notre Dame
02:30 - 03:15 NIH Funding at the Interface
J. Cassatt, NIH (NIGMS)
03:15 - 03:45 Coffee Break
03:45 - 04:15 Contributed Talk
Genetic Regulatory Network Simulations
for Data Analysis
D. Zak, University of Delaware
04:15 - 04:45 Contributed Talk
Structure Identification of Biochemical
Systems with Genetic Algorithms
E. Voit, Medical University of South Carolina
04:45 - 05:30 Poster Session
05:30 - 06:30 Wine and Cheese Reception
TUESDAY, April 09: "Intercellular Level"
08:00 - 08:30 Breakfast & Registration
08:30 - 09:15 Modeling Spontaneous Rhythms in Developing
Spinal Cord
J. Rinzel, New York University
09:15 - 10:00 Modeling Cell Communication in Drosophila
Oogenesis
S. Shvartsman, Princeton University
10:00 - 10:30 Coffee Break
10:30 - 11:15 Structural Complexity and Cellular Information
Processing in Living Cells
D. Ingber, Harvard Medical School
11:15 - 12:00 DIMACS - Celera Genomics/Applied Biosystems Graduate Student Award
Presentation and Lecture
Structure of Gene Expression
S. Rifkin, Yale University
12:00 - 01:30 Lunch
01:30 - 02:00 Contributed Talk
Model-based Analysis of Regulatory Networks
in Bacteria
C. Conradi, Max Planck Institute for Dynamics of
Complex Technical Systems
02:00 - 02:30 Contributed Talk
Dynamic Interactions of cAMP Transients and
Spontaneous Calcium Spikes
Y. Gorbunova, UMDNJ-Robert Wood Johnson Medical School
02:30 - 03:00 Contributed Talk
Establishing Direction During Chemotaxis in
Eukaryotic Cells
W.-J. Rappel, University of California
03:00 - 03:30 Coffee Break
03:30 - 04:00 Contributed Talk
Analysis of a Model of Gradient Sensing in
Dictyostelium and Neutrophils
J. Krishnan, Johns Hopkins University
04:00 - 04:30 Contributed Talk
Human SNPs, System Robustness, and Complex
Disease Traits
J. Moult, University of Maryland Biotechnology Institute
04:30 - 05:30 Poster Session
WEDNESDAY, April 10: "Tissue- & Organ-System Level"
08:00 - 08:30 Breakfast & Registration
08:30 - 09:15 Distributed Feedbacks toward Multiple Conflicting
Goals in the Immune System
L. Segel, Weizmann Institute & Santa Fe Institute
09:15 - 10:00 Modeling T Lymphocyte Dynamics
A. Perelson, Los Alamos National Laboratory
10:00 - 10:30 Coffee Break
10:30 - 11:15 An Integrative Model of the Cardiac Ventricular
Myocyte Incorporating Local-Control of JSR Ca2+
Release
R. Winslow, Johns Hopkins University
11:15 - 12:00 Nonlinear Dynamics, Chaos, and Complexity in
Bedside Medicine
A. Goldberger, Harvard Medical School
12:00 - 01:30 Lunch
01:30 - 02:15 Loss of Complexity with Aging: The Physiologic
Basis of Frailty
L. Lipsitz, Harvard Medical School
02:15 - 03:00 Modeling Malignant Brain Tumors as Complex
Dynamic BioSystems
T. Deisboeck, Harvard Medical School
03:00 - 03:30 Coffee Break
03:30 - 04:00 Contributed Talk
A New Paradigm for B-Cell Activation and Tolerance
G. Bhanot, IBM TJ Watson Research Center and Institute for Advanced Study
04:00 - 04:30 Contributed Talk
Germinal Center Structure Evolution and Affinity
Maturation
S. Kleinstein, Princeton University
04:30 - 05:00 Contributed Talk
Benign Cell Boosters: Exploring Novel Cancer
Therapies Through Simulation
C. Maley, Fred Hutchinson Cancer Research Center
Invited Speakers
L. Hood, Institute for Systems Biology
G. Stephanopoulos, Massachusetts Institute of Technology
J. Collins, Boston University
A.-L. Barabasi, University of Notre Dame
J. Cassatt, NIH (NIGMS)
J. Rinzel, New York University
S. Shvartsman, Princeton University
D. Ingber, Harvard Medical School
S. Rifkin, Yale University
L. Segel, Weizmann Institute & Santa Fe Institute
A. Perelson, Los Alamos National Laboratory
R. Winslow, Johns Hopkins University
A. Goldberger, Harvard Medical School
L. Lipsitz, Harvard Medical School
T. Deisboeck, Harvard Medical School
Posters
Christian S. Parry and Lawrence J. Stern,
Massachusetts Institute of Technology
Crystallographic and Computational Studies of a Class II MHC
Complex with a Nonconforming Peptide: the Preliminary
Structure of HLA-DRA/DRB3*0101
Myung Ho Kim, Ph.D, Chief Scientific Officer of Bioinformatics Frontier Inc.
Pattern Recognition of Protein 2D Gel Image and its Application for
Diagnosis of a Disease
Leo Hellerman
Representation of Living Forms by Information-Theoretic Functions
of Integer Partitions.
Hidirov Bahrom, Saidalieva Mahruy, Hidirova Mohiniso,
Institute of Cybernetics, Academy of Sciences of Uzbekistan
Object-oriented Modeling Of Regulatory Mechanisms Of Living
System on molecular-genetic, cellular and tissue levels.
Katarzyna Rejniak, Tulane University
A computational model of the mechanism of growth of a
trophoblast tissue.
Gordana Apic, S.A. Teichmann, MRC Laboratory of Molecular
Biology; and W. Huber, German Cancer Research Center
Evolution of Multi-Domain Protein Families in Archaeal,
Bacterial and Eukaryotic Proteomes.
M. Madan Babu and Sarah Teichmann, MRC Laboratory of Molecular Biology
Protein Families and Regulatory Patterns in the Transcription
Factor Regulatory Network in E. coli
Sui Huang and Donald E. Ingber, Harvard Medical School
Gene network topology and dynamics in mammalian cell fate regulation
Valentin A. Ilyin and Andrej Sali, The Rockefeller University
ModView, a web application for visualization of multiple protein
sequences and structures.
David Harlan Wood, University of Delaware
DNA Evolution Without Phenotypes
T. Sauter, Eric Bullinger, F. Allgower and E.D. Gilles
Hypothese Testing in Escherichia coli using Mathematical Modeling
Sungchul Ji, Rutgers University; Ming Ouyang, and
Panos Georgopoulos, UMDNJ-RWJ Medical School;
Microarray Data Analysis based on the Bayesian Theorem
and the Entropy Maximization Principle
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Document last modified on March 13, 2003.