Ordering Clone Libraries in Computational Biology

Alan Michael Frieze

Dept. of Mathematics, Carnegie Mellon University, Pittsburgh PA 15213

We consider a probabilistic model, due to Lander and Waterman and to Alizadeh, Karp, Newberg and Weisser, for the physical mapping of DNA molecules. Within this model, we answer precisely a question of Alizadeh et al concerning the minimum number of probes required to reconstruct the entire ordering of a given clone library with high probability. We also examine the related problem of determining the least number of probes required to construct a "spine" for the library. We give a fairly precise characterization for this number.

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Document last modified on March 28, 2000.