DIMACS/IAS Workshop on Genomic Instability in Cancer: Biological and Mathematical Approaches

June 8 - 9, 2004
Institute for Advanced Study, Princeton, New Jersey

Organizers:
Natalia Komarova, Rutgers University and Institute for Advanced Study, Princeton, natalia@ias.edu
Arnold Levine, Institute for Advanced Study, Princeton, and Robert Wood Johnson School of Medicine and Dentistry
Presented under the auspices of the Special Focus on Computational and Mathematical Epidemiology.
Jointly sponsored by the Institute for Advanced Study.

Workshop Program:

This is a preliminary program.

Each lecturer will speak for 30 minutes, followed by 15 minutes for Questions/Discussion. 

Tuesday, June 8, 2004

 8:30 -  9:00  Coffee Available

 9:00 -  9:15  Welcome and Introduction

 9:15 - 10:00  Genomic Instability in Aging Somatic and Germ Line Cells
               George M. Martin, University of Washington

10:00 - 10:45  Evidence that Some Microsatellite Variation is Functional
               Christopher J. Wills, University of California at San Diego
              
10:45 - 11:00  Coffee Break

11:00 - 11:45  Does cancer solve an optimization problem?
               Natalia L. Komarova, Rutgers University & Institute for Advanced Study
              
11:45 - 12:30  Mutator Phenotype in Cancer
               Lawrence Loeb, University of Washington

12:30 -  1:30  Lunch Break

 1:30 -  2:15  Transposable elements and genome instability
               Abram Gabriel, Rutgers University

 2:15 -  3:00  The potential role of retrotransposons in genomic instability of cancers
               Chris Harris, Verto Institute
               
 3:00 -  3:30  Afternoon Tea Break

 3:30 -  4:15  DNA damage and genetic instability: insights from mathematical models
               Dominik Wodarz, University of California at Irvine

 4:15 -  5:00  Phenotypic variation, hyper-mutation and the success of antibiotic
               treatment: some theory and real work (experiments)
               Bruce R. Levin, Emory University

Wednesday, June 9, 2004	

 8:30 -  9:00  Coffee Available

 9:00 -  9:15  Day Two Opening Comments

 9:15 - 10:00  Understanding the somatic genetic basis of prostate cancer
               William R. Sellers, Dana-Farber Cancer Institute
              
10:00 - 10:45  Measuring gene copy differences in cancer and normal genomes
               Michael Wigler, Cold Spring Harbor Laboratory
               
10:45 - 11:00  Coffee Break

11:00 - 11:45  Simple models of predisposition, progression, and epidemiology
               Steven A. Frank, University of California at Irvine
               
11:45 - 12:30  Somatic evolution of cancer
               Martin A. Nowak, Harvard University
               
12:30 -  1:30  Lunch Break

 1:30 -  2:15  Is it necessary to invoke genomic instability to explain 
               cancer rates in human populations?
               Suresh H. Moolgavkar, Fred Hutchinson Cancer Research Center

 2:15 -  3:00  The Forms Of Genomic Instability In Colorectal Cancer
               Richard Boland, Baylor University Medical Center

 3:00 -  3:45  Negative Clonal Selection in Tumor Evolution: Relative Importance 
               of Dominant and Recessive Reduced Fitness Mutations
               Robert A. Beckman, Centocor, Inc.

 3:45 -  4:30  Afternoon Tea - Fuld Hall Common Room
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Document last modified on May 25, 2004.