ORGANIZERS:  Jan Albert, J. Bradac, Andrew  L. Brown, David Hillis,
	     Marcia Kalish, Dennis Pearl, and Tom J. White

			WEDNESDAY, MAY 3

Morning 8:30 a.m. - 12:00 noon, Break 10:00-10:30

Introductions:

 Fred Roberts:  DIMACS Special Year in Mathematical Support for
	        Molecular Biology

 Marcia Kalish:  Short introduction on the overall purpose of the
	         conference

SESSION I:  WHAT ARE THE IMPLICATIONS OF GLOBAL GENETIC VARIATION?
            Chairs:  Beatrice Hahn and David Hillis

 Beatrice Hahn --  Primate lentiviruses

 Francine McCutchan --  HIV subtypes and biological differences

 Bette Korber --  Overview of the HIV sequences database

 David Hillis --  Critique

Lunch 12:00 - 1:30 p.m.

Afternoon 1:30 - 5:00,  Break:  3:00 - 3:30


SESSION II:  NEW APPROACHES FOR ANALYSIS OF HIV TRANSMISSION.
	     Chairs:  Marcia Kalish and Ed Holmes

 Ed Holmes -- Estimating rates of HIV transmission using
              phylogenetic trees

 Jan Albert -- Comparing "true" and molecular trees in a
               heterosexual transmission chain

 Nick Goldman -- Are models of HIV evolution realistic?  
                 [Maximum likelihood method]

 Chi-Cheng Luo/W.-S. Li -- Criteria for when one can say sequences are
                           significantly linked, "undetermined," or are
                           NOT related

 Keith Crandall -- "Statistical parsimony":  a new method for viral
                   phylogenetic analysis

Evening Session, 5:30 - 7:30

  Poster session/informal reception (posters will remain up for the entire
  conference)


			THURSDAY, MAY 4

Morning, 8:30 - 12:00, Break 10:00 - 10:30

SESSION III:  NEW "STATISTICAL" METHODS IN MOLECULAR GENETICS AND HOW THEY CAN
              HELP.  Chairs:  Dennis Pearl and Nick Goldman

 Walter Fitch --  Number and frequency of unsampled haplotypes;
                  analyses of signature sequences

 D. Critchlow --  A new method for measuring the correlation
                  between position in a phylogeny and a covariate

 Terry Speed --   Problems with analysis of HIV variation

 Peter Bickel --  Covariability of V3 loop amino acids

Lunch:  12:00 - 1:30

Afternoon, 1:30 - 5:00, BREAK 3:00 - 3:30


SESSION IV:  THE ROLE OF LINKAGE AND RECOMBINATION IN HIV VARIATION; SAMPLING
             ISSUES.  Chairs:  Paul Sharp and Tom White

 Paul Sharp -- Recombination in AIDS viruses


 F. Seillier-Moiseiwitsch -- Novel statistical methods for analyzing
                             genetic variability

 Simoe Wain-Hobson -- Tissue specificity/distribution and the role
                      of chance in HIV evolution (tentative title)

 John Coffin --  HIV replication dynamics: the most important
                 determinant in genetic variation

 Mark Rayfield -- Evidence for mixed infections

Evening Banquet and talk: Bruce Weir:  Presentation of genetic typing data in
				       court


			FRIDAY, MAY 5

Morning, 8:30 - 12:00, Break 10:00 - 10:30

SESSION V:  VIRAL DYNAMICS  Chairs:  Andrew Leigh Brown and George Shaw

 Andy Brown -- Comparison of evolutionary processes in
               mother-child and adult sexual transmission

 George Shaw -- Viral population half-lives and turnover rates

 A. Perelson -- Modeling quantitative drug-resistance data

 Jean-Pierre Vartanian --Induced mutation?  Effect of dNTP pool
                         imbalances on HIV replication, deletions, 
                         and G to A hypermutation

 Jim Mullins' lab -- How viral populations in various tissues 
                     change over time as a function of disease
                     state and rate of progression

Lunch, 12:00 - 1:30

Afternoon, 1:30 - 6:00,  Break:  3:00 - 3:30


SESSION VI:  ANALYSIS OF TRANSMISSION CASES AND OPEN ISSUES.
	     Chairs:  Jan Albert and Alan Perelson

 Andy Brown -- Comparison of variation in the env and RT
               genes in an individual over time

 Jan Albert -- Molecular and biological analyses of non-
               subtype B transmissions: experience from 
               forensic cases

 Marcia Kalish -- "Clusters:" likelihood of phylogenetic 
                  clustering of HIV-1 strains within a random
	          population

 Carla Kuiken -- Risk group-related differences in the Amsterdam
                 epidemic

Close, 5:00

Summary by organizers of open issues and need for additional methods
development

CONFERENCE ENDS AT 6:00 P.M.

Tom White
Phone 510-814-2837
Fax 510-522-1966

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