This special focus is jointly sponsored by the Center for Discrete Mathematics and Theoretical Computer Science (DIMACS), the Biological, Mathematical, and Physical Sciences Interfaces Institute for Quantitative Biology (BioMaPS), the Rutgers Center for Molecular Biophysics and Biophysical Chemistry (MB Center), and the Division of Life Sciences.
This workshop is jointly sponsored with Robert Wood Johnson Medical School Center for Clinical and Translational Sciences and Amicus Therapeutics.
Thursday, April 20, 2006 8:15 - 9:00 Breakfast and Registration 9:00 - 9:15 Welcoming Remarks Mel Janowitz, DIMACS Associate Director Session Chair: Jean Baum, Rutgers University 9:15 - 9:45 Amyloid Formation by Islet Amyloid Polypeptide Daniel Raleigh, University of New York at Stony Brook 9:45 - 10:15 Molecular structures of fibrils associated with amyloid diseases and yeast prions Rob Tycko, Laboratory of Chemical Physics, NIDDK, National Institutes of Health 10:15 - 10:45 Break Session Chair: David Talaga, Rutgers University 10:45 - 11:15 Toward a Molecular Level Understanding of Polyglutamine Aggregation Rohit Pappu, Washington University in St.Louis 11:15 - 11:45 Kinetics and thermodynamics of amyloid fibril formation Ron Wetzel, University of Tennessee 11:45 - 12:05 Computational Method for Rapidly Predicting Amyloidogenic Sequences in Proteins and Polypeptides William Welsh, Robert Wood Johnson Medical School (UMDNJ) 12:15 - 2:00 Lunch Session Chair: Clay Bracken, Weill Medical College of Cornell University 2:00 - 2:30 Folding and aggregation of a β-clam protein in the test tube and in the cell Lila Gierasch, University of Massachusetts, Amherst 2:30 - 3:00 Structural studies of amyloid-like fibrils Shilpa Sambashivan, UCLA 3:00 - 3:30 Catalytic origins of protein misfolding in end-stage renal disease Andrew Miranker, Yale University 3:30 - 4:00 Break 4:00 - 4:30 Early events in aggregation of prion proteins and Aß peptides Dave Thirumalai, University of Maryland 4:30 - 5:00 Computer simulation of protein fibrillization: polyalanine, poly glutamine and beta amyloid Carol Hall, North Carolina State University 5:00 - 6:30 Poster Session 6:30 Buffet Dinner at DIMACS Friday, April 21 2006 8:15 - 9:00 Breakfast and Registration Session Chair: Barbara Brodsky, Robert Wood Johnson Medical School 9:00 - 9:30 SNPs, Protein structure and disease John Moult, University of Maryland Biotechnology Institute 9:30 - 10:00 Human non-synonymous SNPs: molecular function, evolution and disease Shamil Sunyaev, Brigham & Women's Hospital and Harvard Medical School 10:00 - 10:30 The effect of missense mutations in the N-terminus of BRCA1 on ubiquitin ligase activity and their relationship to breast cancer susceptibility Ellen Solomon, King's College London School of Medicine, Guy's Hospital 10:30 - 11:00 Break Session Chair: Helen Berman, Rutgers University 11:00 - 11:30 Large-scale annotation of coding non-synonymous SNPs: theory and practice Rachel Karchin, University of California 11:30 - 12:00 Stability and compensated pathogenic deviations Fyodor Kondrashov, University of California 12:00 - 1:15 Lunch Session Chair: Ron Levy, Rutgers University 1:15 - 1:45 Protein Intrinsic Disorder, Cell Signaling, and Alternative Splicing Keith Dunker, Indiana University School of Medicine 1:45 - 2:15 Sequence dependence of amyloid formation and toxicity Luis Serrano, EMBL 2:15 - 2:30 Wrap-up