DIMACS Workshop on Computational/Experimental Approaches to Protein Defects in Human Disease

April 20 - 21, 2006
DIMACS Center, CoRE Building, Rutgers University

Jean Baum, Rutgers University, baum@rutchem.rutgers.edu
Barbara Brodsky, UMDNJ, brodsky@umdnj.edu
Presented under the auspices of the DIMACS/BioMaPS/MB Center Special Focus on Information Processing in Biology.

This special focus is jointly sponsored by the Center for Discrete Mathematics and Theoretical Computer Science (DIMACS), the Biological, Mathematical, and Physical Sciences Interfaces Institute for Quantitative Biology (BioMaPS), the Rutgers Center for Molecular Biophysics and Biophysical Chemistry (MB Center), and the Division of Life Sciences.

This workshop is jointly sponsored with Robert Wood Johnson Medical School Center for Clinical and Translational Sciences and Amicus Therapeutics.

Workshop Program:

Thursday, April 20, 2006

 8:15 -  9:00  Breakfast and Registration 

 9:00 -  9:15  Welcoming Remarks
               Mel Janowitz, DIMACS Associate Director

Session Chair: Jean Baum, Rutgers University

 9:15  - 9:45  Amyloid Formation by Islet Amyloid Polypeptide
               Daniel Raleigh, University of New York at Stony Brook

 9:45 - 10:15  Molecular structures of fibrils associated with 
               amyloid diseases and yeast prions
               Rob Tycko, Laboratory of Chemical Physics, NIDDK, National Institutes of Health

10:15 - 10:45  Break

Session Chair: David Talaga, Rutgers University

10:45 - 11:15  Toward a Molecular Level Understanding of Polyglutamine Aggregation 
               Rohit Pappu, Washington University in St.Louis

11:15 - 11:45  Kinetics and thermodynamics of amyloid fibril formation 
               Ron Wetzel, University of Tennessee
11:45 - 12:05  Computational Method for Rapidly Predicting Amyloidogenic
               Sequences in Proteins and Polypeptides
               William Welsh, Robert Wood Johnson Medical School (UMDNJ) 

12:15 -  2:00  Lunch

Session Chair: Clay Bracken, Weill Medical College of Cornell University

 2:00 -  2:30  Folding and aggregation of a β-clam protein in 
               the test tube and in the cell 
	       Lila Gierasch, University of Massachusetts, Amherst

 2:30 -  3:00  Structural studies of amyloid-like fibrils
               Shilpa Sambashivan, UCLA

 3:00 -  3:30  Catalytic origins of protein misfolding in end-stage renal disease
               Andrew Miranker, Yale University 

 3:30 -  4:00  Break
 4:00 -  4:30  Early events in aggregation of prion proteins and Aß peptides
               Dave Thirumalai, University of Maryland

 4:30 -  5:00  Computer simulation of protein fibrillization: 
               polyalanine, poly glutamine and beta amyloid
               Carol Hall, North Carolina State University

 5:00 -  6:30  Poster Session
 6:30	       Buffet Dinner at DIMACS

Friday, April 21 2006

 8:15 -  9:00  Breakfast and Registration

Session Chair: Barbara Brodsky, Robert Wood Johnson Medical School

 9:00 -  9:30  SNPs, Protein structure and disease 
               John Moult, University of Maryland Biotechnology Institute             

 9:30 - 10:00  Human non-synonymous SNPs: molecular function, evolution and disease
               Shamil Sunyaev, Brigham & Women's Hospital and Harvard Medical School

10:00 - 10:30  The effect of missense mutations in the N-terminus of BRCA1 on 
               ubiquitin ligase activity and their relationship to breast cancer susceptibility 
               Ellen Solomon, King's College London School of Medicine, Guy's Hospital 

10:30 - 11:00  Break

Session Chair: Helen Berman, Rutgers University

11:00 - 11:30  Large-scale annotation of coding non-synonymous SNPs: 
               theory and practice
	       Rachel Karchin, University of California

11:30 - 12:00  Stability and compensated pathogenic deviations
               Fyodor Kondrashov, University of California

12:00 -  1:15  Lunch

Session Chair: Ron Levy, Rutgers University

 1:15 -  1:45  Protein Intrinsic Disorder, Cell Signaling, and Alternative Splicing
               Keith Dunker, Indiana University School of Medicine

 1:45 -  2:15  Sequence dependence of amyloid formation and toxicity
               Luis Serrano, EMBL

 2:15 -  2:30  Wrap-up 

Previous: Participation
Next: Registration
Workshop Index
DIMACS Homepage
Contacting the Center
Document last modified on April 18, 2006.