This special focus is jointly sponsored by the Center for Discrete Mathematics and Theoretical Computer Science (DIMACS), the Biological, Mathematical, and Physical Sciences Interfaces Institute for Quantitative Biology (BioMaPS), the Rutgers Center for Molecular Biophysics and Biophysical Chemistry (MB Center), and the Division of Life Sciences.
This workshop is jointly sponsored with Robert Wood Johnson Medical School Center for Clinical and Translational Sciences and Amicus Therapeutics.
Thursday, April 20, 2006
8:15 - 9:00 Breakfast and Registration
9:00 - 9:15 Welcoming Remarks
Mel Janowitz, DIMACS Associate Director
Session Chair: Jean Baum, Rutgers University
9:15 - 9:45 Amyloid Formation by Islet Amyloid Polypeptide
Daniel Raleigh, University of New York at Stony Brook
9:45 - 10:15 Molecular structures of fibrils associated with
amyloid diseases and yeast prions
Rob Tycko, Laboratory of Chemical Physics, NIDDK, National Institutes of Health
10:15 - 10:45 Break
Session Chair: David Talaga, Rutgers University
10:45 - 11:15 Toward a Molecular Level Understanding of Polyglutamine Aggregation
Rohit Pappu, Washington University in St.Louis
11:15 - 11:45 Kinetics and thermodynamics of amyloid fibril formation
Ron Wetzel, University of Tennessee
11:45 - 12:05 Computational Method for Rapidly Predicting Amyloidogenic
Sequences in Proteins and Polypeptides
William Welsh, Robert Wood Johnson Medical School (UMDNJ)
12:15 - 2:00 Lunch
Session Chair: Clay Bracken, Weill Medical College of Cornell University
2:00 - 2:30 Folding and aggregation of a β-clam protein in
the test tube and in the cell
Lila Gierasch, University of Massachusetts, Amherst
2:30 - 3:00 Structural studies of amyloid-like fibrils
Shilpa Sambashivan, UCLA
3:00 - 3:30 Catalytic origins of protein misfolding in end-stage renal disease
Andrew Miranker, Yale University
3:30 - 4:00 Break
4:00 - 4:30 Early events in aggregation of prion proteins and Aß peptides
Dave Thirumalai, University of Maryland
4:30 - 5:00 Computer simulation of protein fibrillization:
polyalanine, poly glutamine and beta amyloid
Carol Hall, North Carolina State University
5:00 - 6:30 Poster Session
6:30 Buffet Dinner at DIMACS
Friday, April 21 2006
8:15 - 9:00 Breakfast and Registration
Session Chair: Barbara Brodsky, Robert Wood Johnson Medical School
9:00 - 9:30 SNPs, Protein structure and disease
John Moult, University of Maryland Biotechnology Institute
9:30 - 10:00 Human non-synonymous SNPs: molecular function, evolution and disease
Shamil Sunyaev, Brigham & Women's Hospital and Harvard Medical School
10:00 - 10:30 The effect of missense mutations in the N-terminus of BRCA1 on
ubiquitin ligase activity and their relationship to breast cancer susceptibility
Ellen Solomon, King's College London School of Medicine, Guy's Hospital
10:30 - 11:00 Break
Session Chair: Helen Berman, Rutgers University
11:00 - 11:30 Large-scale annotation of coding non-synonymous SNPs:
theory and practice
Rachel Karchin, University of California
11:30 - 12:00 Stability and compensated pathogenic deviations
Fyodor Kondrashov, University of California
12:00 - 1:15 Lunch
Session Chair: Ron Levy, Rutgers University
1:15 - 1:45 Protein Intrinsic Disorder, Cell Signaling, and Alternative Splicing
Keith Dunker, Indiana University School of Medicine
1:45 - 2:15 Sequence dependence of amyloid formation and toxicity
Luis Serrano, EMBL
2:15 - 2:30 Wrap-up
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