Nucleic acid selection, or directed molecular evolution, allows the identification of molecules with unique functional properties from large pools of random sequences. This technology has pushed molecular biology towards DNA computing, which also uses combinatorial searches to find molecules that satisfy a unique set of filters. The goal of this workshop is to explore recent advances in test-tube evolution experiments that can be transported to DNA computing.
Invited speakers and topics:
Andrew Ellington (Indiana University)
Natural and artificial RNA evolution
Robert Dorit (Yale University)
In vitro evolution of complexity
Mike Yarus (University of Colorado)
The hypothetical RNA world
Pim Stemmer (Maxygen, Inc.)
DNA and protein shuffling
Barry Polisky (NeXstar Pharmaceuticals, Inc.)
SELEX
Dinshaw J. Patel (Memorial Sloan-Kettering)
Comparative aptamer complexes
Niles Lehman (SUNY Albany)
Continuous ribozyme evolution
Dipankar Sen (Simon Fraser University)
DNA enzymes
Peter Unrau (Whitehead Institute, MIT)
Nucleotide forming ribozymes
Michael Hecht (Princeton University)
Protein evolution and design
Michael Famulok (Institut fur Biochemie, Munich)
In vitro selection
Donald Burke (University of Colorado)
Chimeric SELEX
Steve Benner (University of Florida)
Evolution of natural biopolymers
Sydney Brenner (Molecular Sciences Institute)
to be announced
Michael Heller (Nanogen, Inc.)
Hybridization to electronic arrays
We invite papers and poster presentations on any topic related to molecular selection and DNA computing. Please send a title and abstract to Sandy Barbu, barbu@cs.princeton.edu by February 1, 1998.
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