Nucleic acid selection, or directed molecular evolution, allows the identification of molecules with unique functional properties from large pools of random sequences. This technology has pushed molecular biology towards DNA computing, which also uses combinatorial searches to find molecules that satisfy a unique set of filters. The goal of this workshop is to explore recent advances in test-tube evolution experiments that can be transported to DNA computing.
Invited speakers and topics:
Andrew Ellington (Indiana University) Natural and artificial RNA evolution Robert Dorit (Yale University) In vitro evolution of complexity Mike Yarus (University of Colorado) The hypothetical RNA world Pim Stemmer (Maxygen, Inc.) DNA and protein shuffling Barry Polisky (NeXstar Pharmaceuticals, Inc.) SELEX Dinshaw J. Patel (Memorial Sloan-Kettering) Comparative aptamer complexes Niles Lehman (SUNY Albany) Continuous ribozyme evolution Dipankar Sen (Simon Fraser University) DNA enzymes Peter Unrau (Whitehead Institute, MIT) Nucleotide forming ribozymes Michael Hecht (Princeton University) Protein evolution and design Michael Famulok (Institut fur Biochemie, Munich) In vitro selection Donald Burke (University of Colorado) Chimeric SELEX Steve Benner (University of Florida) Evolution of natural biopolymers Sydney Brenner (Molecular Sciences Institute) to be announced Michael Heller (Nanogen, Inc.) Hybridization to electronic arrays
We invite papers and poster presentations on any topic related to molecular selection and DNA computing. Please send a title and abstract to Sandy Barbu, firstname.lastname@example.org by February 1, 1998.
poster of the workshop