### Workshop on DNA Topology and Structure

#### December 9, 1994

DIMACS Center, CoRE Building, Rutgers University, Piscataway, NJ

**Organizer:**
**Craig Benham**, Mt. Sinai Med., BENHAM@msvax.mssm.edu
** Bill Bauer**, Stony Brook

Presented under the auspices of the DIMACS Special Year in Mathematical Support for Molecular Biology.

In vivo DNA is partitioned into discrete domains, either as complete
closed circular molecules or as loops within linear molecules. This
imposes a topological constraint on each domain by which its linking
number is fixed. (The linking number is the number of times either
strand links through the loop formed by the other strand.) The value
of this linking number is carefully regulated by enzymes. Many
important biological events are modulated by the topological state of
the domain involved, including the initiation of gene expression and
of DNA replication.

This workshop will focus on the topological aspects of DNA structure
and function that are of greatest biological importance. Topics
covered will include the nature of the topological constraints on DNA,
and how the resulting stresses affect the folding and the helical
structure of the DNA. Dynamical, statistical and mechanical
approaches to the analysis of topologically constrained DNA structures
will be presented. In addition, topological methods used to determine
the mechanisms of activity of enzymes that transiently cut and
rearrange DNA strands will be described.

The following speakers will give lectures in this workshop:

- William R. Bauer, Microbiology Dept., SUNY - Stony Brook
- Craig J. Benham - Biomathematical Sciences Dept., Mount Sinai
- John Maddocks, Math Dept., University of Maryland
- Tamar Schlick, Courant Institute, NYU
- Ned Seemans, Chemistry Dept., NYU
- DeWitt Sumners, Math Dept., Florida State University
- Alex Vologodskii, Chemistry Dept., NYU

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Document last modified on November 1, 1994