This course is presented as part of the BioMaPS Summer School. It is jointly sponsored by the BioMaPS Institute for Quantitative Biology, the Center for Discrete Mathematics and Theoretical Computer Science (DIMACS), the Rutgers Center for Molecular Biophysics and Biophysical Chemistry (MBBC), the Program in Mathematics and Molecular Biology based at Florida State University (PMMB) and the Rutgers Center for Systems and Control (SYCON).
Presented under the auspices of the DIMACS/BioMaPS/MB Center Special Focus on Information Processing in Biology.
Monday, June 6, 2005
8:30 - 9:00 Breakfast and Registration
9:00 - 9:15 Welcome and Opening Remarks
Paul Ehrlich, BioMaPS Administrative & Assoc. Graduate Program Director
Introduction to the course
9:30 - 10:30 What is signal transduction?
Stanislav Shvartsman, Princeton University -
Genomics Institute, Chem. Eng.
10:30 - 11:00 Break
11:00 - 12:00 Stanislav Shvartsman (continued)
12:00 - 2:00 Lunch
2:00 - 3:00 Overview of signaling in bacteria
Igor Zhulin, Georgia Tech- Biology
3:00 - 3:15 Break
3:15 - 4:15 Igor Zhulin (continued)
5:15 Reception
6:00 Dinner
Tuesday, June 7, 2005
9:30 - 10:30 Introduction to two-component signaling
Ann Stock, UMDNJ - Biochemistry
10:30 - 11:00 Break
11:00 - 12:00 Ann Stock (continued)
12:00 - 1:15 Lunch
1:15 - 2:15 Introduction to bacterial motility & chemotaxis
Robert Bourret, University of North Carolina - Microbiology
2:15 - 2:30 Break
2:30 - 3:30 Robert Bourret (continued)
3:30 - 4:00 Break
4:00 - 4:30 Molecular evolution of the MCP signaling domain
Roger Alexander, Georgia Tech-Biology
4:30 - 5:00 Significance of alternate binding modes of chemotaxis regulator,
cheY with C-terminal peptide of its phosphatase, cheZ
Jayita Guhaniyogi, University of Medicine and Denistry of NJ-Biochemistry
Wednesday, June 8, 2005
9:30 - 10:00 Practical lessons concerning collaboration between
experimentalists & modelers
Robert Bourret, University of North Carolina - Microbiology
10:00 - 11:00 Adaptation and signal processing in bacterial chemotaxis
Ned Wingreen, Princeton University - Molecular Biology
11:00 - 11:30 Break
11:30 - 12:30 Ned Wingreen (continued)
12:30 - 2:00 Lunch
2:00 - 3:00 Receptor interaction and signal amplification in
bacterial chemotaxis
Yuhai Tu, IBM
3:00 - 3:15 Break
3:15 - 4:15 Introduction to noise in biological systems
William Bialek, Princeton University - Physics
4:15 - 4:30 Break
4:30 - 5:30 Noise in bacterial gene expression
Alexander van Oudenaarden, MIT - Physics
Thursday, June 9, 2005
9:30 - 10:30 Pushing the envelope: How E. coli copes with external stress
Tom Silhavy, Princeton University - Molecular Biology
10:30 - 11:00 Break
11:00 - 12:00 Continuous control in bacterial regulatory circuits
Mark Goulian, University of Pennsylvania - Physics
12:00 - 4:00 Lunch and Poster Session
Friday, June 10, 2005
9:30 - 10:00 Modeling spatial oscillations of Min proteins in round bacteria
Kerwyn Huang, Princeton University- Molecular Biology
10:00 - 10:30 Evolutionary design principles of a bacterial signaling network
Kilian Bartholome, University of Freiburg-Molecular Biology
10:30 - 11:30 Quorum sensing: cell-to-cell communication in bacteria
Bonnie Bassler, Princeton University - Molecular Biology
11:30 - 11:45 Closing Remarks
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