- Tumor evolutionary model incorporating spatial heterogeneity
- Project Year:
2022
- REU Student (s):
Sycamore Herlihy | Worcester Polytechnic Institute MA
- Student 1 Institution:
Worcester Polytechnic Institute
- Project Mentor:
Subhajyoti De
- Project Mentor Area:
Rutgers Cancer Institute of New Jersey
- Project Abstract:
Intratumoral heterogeneity is a feature in the majority of human cancers. The capability to observe the spatiotemporal clonal dynamics in the tumor of a patient is severely limited, raising the need for a mathematical model to further the study of ITH. We present STEDISH, a stochastic mathematical model for tumor growth incorporating the concept of spatiotemporal heterogeneity. STEDISH allows examining the patterns of spatial ITH under different models of tumor evolution and other constraints.
