DIMACS Workshop on Protein Domains: Identification, Classification and Evolution

February 27-28, 2003
DIMACS Center, CoRE Building, Rutgers University

Stephen Bryant, National Institutes of Health, bryant@ncbi.nlm.nih.gov
Teresa Przytycka, National Institutes of Health, przytyck@ncbi.nlm.nih.gov
Presented under the auspices of the Special Focus on Computational Molecular Biology.

Protein domains may be defined as elementary units of protein structure and evolution, capable, to some extent, of folding and functioning autonomously. Understanding of domain structure, function and evolution is a fundamental step towards understanding of a living organism. Identification of protein domains provides an inside into protein function.

Current databases provide a vast amount of protein sequence and structure data, and it is likely that members of the majority of protein families have been already observed. Thus we are in the position to ask a question which could not be addressed previously: Can one use this information to identify domain sequences and structures computationally? How can we extract their properties?

By analyzing the database of known sequences and structures and the properties of conserved domains we hope to get some insight into domain identification, properties and evolution. The amount of the data, it's complexity and biological context open challenges of an interdisciplinary nature. For example, identification of a structural domain requires on one hand sophisticated algorithms that can search for patterns in 3-dimensional data and on the other hand a clear, biologically meaningful and computationally tractable, definition of protein domain.

The workshop is devoted to computational challenges in this new phase of understanding protein domain organization. The goal of the workshop is be to bring together biological and computational/mathematical scientists to discuss the state of art and the open questions focusing on the following aspects of protein domains:

Leading specialists of the field will give invited presentations. There will be a poster session and we invite poster contributions.

Next: Call for Participation
Workshop Index
DIMACS Homepage
Contacting the Center
Document last modified on February 4, 2003.