DIMACS Seminar on Mathematics and Computer Science in Molecular Biology


TGF-b Signal Transduction in Invertebrates


Dr. Richard Padgett
The Waksman Institute, Rutgers University


Seminar Room 431, CoRE Building,
Busch Campus, Rutgers University.


3 PM to 4 PM
Monday, December 12 1994.


The work in my laboratory focuses on the transforming growth factor-b-like (TGF-b- like) molecules and their signal transduction pathway. This growth factor family is found in vertebrates and invertebrates, but little is known about how they transduce their signal to the nucleus. Because of the powerful experimental approaches available in Drosophila and C. elegans, we are using them as model systems to dissect this signal transduction pathway. We are currently studying two aspects of the TGF-b- like molecules. First, we are studying upstream genes that regulate the activity of the growth factor, such as the tolloid and tolkin genes. Secondly, we are studying genes that encode receptors for the Drosophila TGF-b- like genes, with the aim of understanding how the signal is transferred from the receptor to other cytoplasmic molecules. In order to study these processes, we are using molecular genetic and biochemical methods to characterize these genes and to determine how their signals are transduced. As a complement to our Drosophila work, we are characterizing components of this signal transduction pathway in the nematode, C. elegans . Since these growth factors are involved in regulating the growth of many tissues, understanding how they function has important implications in development.

General Announcement:

Coffee and cookies will be served in the 4th floor lounge of the CoRE building before the talk. For further information on this seminar series, contact

Richa Agarwala (agarwala@dimacs.rutgers.edu)
Vineet Bafna (bafna@dimacs.rutgers.edu)
S. Muthukrishnan (muthu@dimacs.rutgers.edu)
R. Ravi (rravi@dimacs.rutgers.edu)

Document last modified on December 10, 1994