DIMACS Seminar on Mathematics and Computer Science in Molecular Biology
Characterizations of a Consensus Method for Molecular Sequences
- William H. E. Day
- Univ. of New Foundland.
- Box 17, Port Maitland
- Nova Scotia B0W 2V0
- Seminar Room 431, CoRE Building,
- Busch Campus, Rutgers University.
- 3 PM to 4 PM. ** Regular time **
- Monday, November 7, 1994
The asymptotic plurality rule, apl, is a consensus function which maps each
profile P of length k (i.e., each sequence of k bases appearing at an aligned
position of k molecules) to a set apl ( P ) of results (i.e., ambiguity codes)
that is a descriptive summary of P. To make apl understandable to users, my
colleagues and I considered several complementary descriptions of apl and its
results. Initially we characterized each consensus result X = apl ( P ) in
terms of the frequencies with which the bases in P occur, and we used the
characterizations to investigate features (e.g., strong consistency) of apl
that researchers might find useful when interpreting apl's consensus results.
Another approach is to characterize the pre-image of each X in terms of linear
combinations of basic partitions. Perhaps apl might even have a plausible
likelihood interpretation. I will discuss such developments as time permits.
My work is part of an on-going collaboration with E. Kubicka, G. Kubicki
and F. R. McMorris at the Department of Mathematics, University of Louisville.
Coffee and cookies will be served
in the 4th floor lounge of the CoRE building before the talk. For
further information on this seminar series, contact
- Richa Agarwala (firstname.lastname@example.org)
- Vineet Bafna (email@example.com)
- S. Muthukrishnan (firstname.lastname@example.org)
- R. Ravi (email@example.com)
Document last modified on November 5, 1994