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Stochasticity and Penetrance in Cancer Predisposition Syndrome

November 21, 2019, 11:45 AM - 12:00 PM


The Heldrich Hotel & Conference Center

10 Livingston Avenue

New Brunswick, NJ 08901


Click here for map.

Chang Chan, Rutgers University

What are the contributions of genetics, environment, and stochasticity to cancer risk? We will present this in the context of a cancer predisposition syndrome where individuals born with a germline mutation in a tumor suppressor gene are at high risk for cancer including having multiple primary tumors in their lifetime. We will specifically address why related mutation carriers have different penetrance for cancer.

Speaker Bio: Chang Chan is Associate Professor of Medicine at Rutgers Robert Wood Johnson Medical School and co-leader of the Genome Instability and Cancer Genetics Program at Rutgers Cancer Institute of New Jersey, a DIMACS partner. Chan has developed and applied quantitative methods to the analysis of genomic, transcriptomic and epigenomic data. His work employs large datasets and models to bring insights into the biology of cancer. Chan has been a mentor in DIMACS REU Program.